Following its transformative impact on implantology and oral surgery through tissue regeneration, this book presents the remarkable and highly successful translation of Plasma Rich in Growth Factors PRGF-ENDORET® technology to the fields of orthopaedic surgery and sports medicine. Its authors, Dr Eduardo Anitua and Dr Mikel Sánchez, bring together fifteen years of intensive research and shared clinical experience, showing how their work has progressed from an initial intuition to the most rigorous scientific evidence. Throughout its chapters, the text leads the reader from the cellular and molecular foundations of regeneration and the pivotal biological role of platelets to the detailed application of PRGF-ENDORET® in the treatment of tendon, muscle, joint, cartilage and bone lesions. It also provides the precise protocols for obtaining and preparing this 100% autologous technology in its different formulations, tailoring it to the specific needs of each patient and pathology. Far from being a purely theoretical manual, the book demonstrates how the use of these biological tools accelerates functional recovery, relieves symptoms and radically changes the prognosis of both elite athletes and ordinary patients, achieving true regenerative processes rather than mere scar repair. It is an indispensable work for orthopaedic surgeons, surgeons and sports physicians seeking to incorporate into their clinical practice one of the greatest and most robust advances in translational regenerative medicine.